About CoolSculpting:

CoolSculpting™ is a patented, non-invasive, clinically proven procedure to selectively reduce fat layers in problem areas using a patented cooling technology. It is a safe procedure cleared by the FDA that gently cools unwanted fat cells in the body to induce a natural, controlled elimination of fat cells. This reduces bulges in treated areas of the body without harming surrounding tissue.

Key Benefits of CoolSculpting:

It involves no needles, surgery or downtime. – Because the CoolSculpting procedure is non-invasive, patients can resume daily activities including work and exercise, immediately following treatment.

It’s easy.

  • CoolSculpting patients can sit or lie comfortably and read, work on their laptop or even nap during the procedure. The procedure is performed in a medical office, under the supervision of physician specializing in cosmetic procedures.

It’s convenient.

  • Procedures last about one to two hours, so treatment can easily be performed during a lunch hour or without major disruption to the day.

The results are dramatic.

  • Patients can expect an average 20-25% reduction.

How CoolSculpting Works

During the CoolSculpting procedure, a non-invasive applicator delivers precisely controlled cooling to the treatment area to specifically target underlying fat, leaving surface skin tissue unaffected. When fat cells are exposed to cold, a process of natural removal is triggered, which gradually reduces the thickness of the fat layer. The result is a visible reduction in fat bulges.

Efficacy

On average, each CoolSculpting procedure results in a 20-25% reduction of fat in the treated areas, and patients can start to see results as soon as three weeks following treatment, with the most dramatic results occurring over a period of two to four months in most patients.

Clinical studies1 involving hundreds of patients show that, for properly selected patients, ZELTIQ’s CoolSculpting procedure is an effective way to reduce fat without the pain, risk, and recovery time of surgical procedures. The result is noticeable, natural-looking fat reduction in the treated areas.

Safety

The CoolSculpting procedure is safe because the delivery of precise cooling affects only targeted fat cells, leaving adjacent tissue unharmed and intact.

Availability

The CoolSculpting procedure by ZELTIQ is available worldwide through an elite network of CoolSculpting Centers. For a list of CoolSculpting providers please visit www.coolsculpting.com.

Target Patient

CoolSculpting by ZELTIQ is not intended as a weight-reduction program for overweight individuals. The best candidates for the CoolSculpting procedure are people near their ideal body weight who eat well and exercise regularly and have pockets of fat that have not responded to a healthy lifestyle. They are seeking spot reduction for specific areas of fat but are not considering a surgical procedure.

Science Behind CoolSculpting

The CoolSculpting procedure developed by ZELTIQ is based on sound science called Cryolipolysis™. Cryolipolysis is the result of a groundbreaking discovery by Drs. Dieter Manstein and R. Rox Anderson of Harvard Medical School and the Wellman Center for Photomedicine at Massachusetts General Hospital in Boston, Massachusetts.

Their initial work, first published in the peer-reviewed professional journal Lasers in Surgery and Medicine, proved that subcutaneous fat cells are naturally more vulnerable to the effects of cold than other surrounding tissue. These studies and other research from centers of excellence confirmed that fat cells, when exposed to precisely controlled cooling for a sustained period of time, undergo a gradual reduction and cell death through a process called “induced apoptosis2”.

Company History

Founded in 2005, ZELTIQ is a global medical device company that developed a patented, non-invasive, clinically proven procedure to selectively reduce fat. It has licensed the commercial rights to Cryolipolysis from Massachusetts General Hospital as a non-invasive method of reducing fat. ZELTIQ is advancing the basic science, clinical evaluation, and commercial development of this technology. The company has developed an advanced medical device that utilizes this new discovery and is making it available to physicians specializing in cosmetic procedures

CoolSculpting 101 Animation from CoolSculpting by ZELTIQ on Vimeo.

Frequently Asked Questions: Patients

Q1.What is the Zeltiq(TM) Procedure?

A1.The Zeltiq Procedure is a new, non-invasive way to gently and effectively reduce fat in targeted areas of your body, resulting in noticeable, natural-looking fat reduction in the treated areas. What makes the Zeltiq Procedure different is its advanced cooling technology that targets and eliminates fat cells. Unlike traditional invasive surgical procedures, the Zeltiq Procedure is non-invasive, with no needles and no incisions. There is no need for anesthesia or pain medications and there is no recovery time. The procedure is performed in a medical office, under the supervision of a physician specializing in cosmetic procedures.

Q2.How does the Zeltiq Procedure work?

A2.Early research done by world-renowned dermatologists at Massachusetts General Hospital in Boston, MA, a teaching affiliate of Harvard Medical School, showed that fat cells are naturally more vulnerable to cold than other surrounding tissue. This scientific principle is called “Cryolipolysis™.” During the procedure, a non-invasive applicator delivers precisely controlled cooling to target and eliminate fat cells in specific areas of your body. When fat cells are exposed to cooling during the Zeltiq Procedure, it triggers a process of natural removal, which gradually reduces the thickness of the fat layer. The result is a reduction in fat bulges that is visible in most patients in two to four months.

Q3. What happens to the fat cells?

A3. The exposure to cooling causes the fat cells to begin a process of natural removal, which gradually reduces the thickness of the fat layer. The fat cells in the treated area are gently eliminated through the body’s normal metabolic processes, like fat from food. The result is a gradual reduction in fat bulges that is visible to most patients in two to four months.

Q4. What clinical evidence shows that the Zeltiq Procedure really works?

A4. Clinical studies2 involving hundreds of patients show that, for properly selected patients, the Zeltiq Procedure is an effective way to reduce fat without the pain, risk, and recovery time of surgical procedures. The result is noticeable, natural-looking fat reduction in the treated areas.

Q5. How long until I notice results?

A5. In properly selected patients, the Zeltiq Procedure results in a noticeable, measurable reduction in fat bulges in two to four months. At that time, you and your doctor can meet to assess your cosmetic improvement and consider additional Zeltiq Procedures to achieve greater fat reduction.

Q6.How do the results compare with invasive procedures like liposuction?

A6. The results of the Zeltiq Procedure are not as rapid or dramatic as invasive procedures such as liposuction. However, if you want to avoid the pain, risk and recovery time associated with surgical procedures, the Zeltiq Procedure may be the preferred option for you.

Q7. How long do the results last?

A7. Patients experiencing fat layer reduction show persistent results at least six months after the Zeltiq Procedure. Longer term studies have not been completed. The elimination of fat cells as a result of the Zeltiq Procedure is expected to last about as long as fat cells removed by invasive procedures such as liposuction.

Q8. What are common effects after the procedure?

A8. The Zeltiq Procedure is completely non-invasive, which allows return to normal activities on the same day as the procedure, such as work or exercise. Redness may appear in the treated area, and may last from a few minutes to a few hours. Some localized bruising may occur, which clears within a few weeks. Many patients experience a temporary dulling of sensation in the treated area lasting one to eight weeks.

Q9. How long does the procedure take?

A9. Procedure time can be two hours or more depending on the size of the area to be treated. During your consultation, your doctor will discuss how long your procedure will take and how much time you should allow for your office visit.

Q10. Does the Zeltiq Procedure hurt?

A10. The Zeltiq Procedure is comfortable for most patients3. No anesthesia was needed for any patients in clinical trials2. Typically patients are comfortable enough to read, work on their laptop computers, listen to music, or just relax during the procedure.

Q11. Is there downtime after the Zeltiq Procedure?

A11. There is no recovery time after the Procedure. You may resume your normal activities on the same day as your procedure, including work and exercise.

Q12. Will I benefit from additional Zeltiq Procedures?

A12. A follow-up visit should be scheduled with your doctor two to four months after your procedure to assess your cosmetic improvement and consider additional Zeltiq Procedures to achieve greater fat reduction.

Q13. Am I a good candidate for the Zeltiq Procedure?

A13. Ideal candidates for the Zeltiq Procedure are relatively fit, but have some modest-size fat bulges that are not easily reduced through diet and exercise. They are seeking spot reduction for specific areas of fat, but are not considering a surgical procedure. The Zeltiq Procedure is not a way to lose weight or treat obesity, and it is not a substitute for invasive methods like liposuction. During a consultation, your doctor can talk with you about whether you are a good candidate for the Zeltiq Procedure.

Q14. How is the Zeltiq Procedure different from other procedures?

A14. The controlled cooling of the Zeltiq Procedure targets and eliminates only fat cells. Other treatment modalities such as lasers, radiofrequency, and focused ultrasound affect fat cells and may affect other adjacent tissue in a way that is not comparable to the Zeltiq method of cryolipolysis.

Q15. Who is Zeltiq Aesthetics?

A15. Zeltiq Aesthetics is a science-based medical device company located in the San Francisco Bay Area. It has licensed the commercial rights to cryolipolysis from Massachusetts General Hospital as a non-invasive method of reducing fat. Zeltiq Aesthetics is advancing the basic science, clinical evaluation, and commercial development of this technology. The Company has developed an advanced medical device that utilizes this new discovery, and is making it available to physicians specializing in cosmetic procedures.

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